Born in Mannheim, Germany, Brigitte Hofherr grew up in Ladenburg, a small village surrounded by fields and small gardens. She was drawn to nature and art, and has been painting since childhood. Self-taught in art, she had her first exhibition at the German Cancer Research Center(DKFZ) in Heidelberg in 1996.

As her work became known, she was invited to a vineyard in Stellenbosch, South Africa and was commissioned to make four botanical paintings. During her stay there she visited the Kirstenbosch botanical garden in Cape Town. Later, she started to travel to various countries every year, such as Greece, Italy, Turkey, Switzerland and France, in search of new plants and subjects for her art.

It is crucial for her to feel drawn to the object she is to paint. Working with oil on canvas, she usually makes large-scale works. Based on her own photographs, she focuses on the morphology of the plants and tries to arrive at a composition which leaves viewers with a lasting aesthetic impact. She is also interested in channeling the viewer's attention to the plants themselves, the environment and the protection of biodiversity.

She has spent over four years on the project of ”historical apple varieties“. Research has brought her in contact with apple growers, fruit-grove owners and scientists throughout Europe. The paintings from this series are scheduled to be exhibited at the Gartenbaumuseum Erfurt / (Germany) in March 2023.

She has exhibited her work at many galleries in Germany and Europe, and her paintings can be found in several private and public collections. She is a member of the American Society of Botanical Artists (ASBA), the Botanical Art Forum of Thüngersheim (Germany), the Vahle Cultural institute of Darmstadt (Germany) and GEDOK Mannheim / Ludwigshafen (Germany